No one was over-burdened by too much prior study of the Player's Handbook, but everybody found it easy enough to use--particularly in comparison to some older editions. A outline of character creation with page references would have been a help, though.
We wound up with a frox thief, a human bard, an infernal-blood (don't call 'em tieflings!) sorcerer, a human fighter, a wood elf ranger, and an Azurthite dwarf cleric of Iolanthe. A fairly non-muscle heavy bunch, but the ranger and fighter ought to be able to handle it.
I'm planning on running this more sandboxy than my "mission style" approach to Weird Adventures. After the first adventure, the player's will get a list of rumors/adventure seeds to choose from for the next session--a technique I've seen put to good use in Chris Kutalik's Hill Cantons game.
The players seem eager to get started and so am I.