The Spire is a tower city in the middle of a desert. A desert (we discover in this issue) that has air toxic to humans, at least with repeated exposure. This also ties in to the origin of "the Skews," the strange, near humans that suffer prejudice within the city. They were apparently made in the "Antiki" times to live places and do things humans could not. Watch Commander Shå is a Skew. She's also trying to solve a series of murders.
There's a serial killer in the lower city who has ties to the high class upper part of town, according to a couple of tracker animals. Then there's an apparent attempt on the life of the Marchioness, the mother of the newly ascended Baroness that instead takes the life of her nursemaid.
Meanwhile, religious zealots in the deserts are massing, and a messanger sent at the death of the old baron is returning to the Spire with a mysterious group of Sculpted (the polite name for Skews).
I suspect all these things tie in together and to the history of the Spire. Still a lot of worldbuilding in this issue (which isn't bad, but any means) but the mystery seems to be picking up steam, even if the main characters don't seem to know it yet.