It's been a while since I reviewed The Spire, but you can read the about the previous issues here. Now the Tithebound, various tribes of nonhuman "skews", arrive at the Spire to pledge their allegiance once again. The Medusi (the people of our heroine, Shå) break protocol by escaping that they be allowed to take the fugitive Soulbreaker with them. That's complicated by the fact nobody knows what the Soulbreaker looks like.
Meanwhile, Shå is trying to catch a serial killer who's stalking the Spire--and seems to be able to get into locked rooms and disappear swiftly. A dagger with an unusual symbol is left at one of the crime scenes.
We also find out that Shå's past is a bit mysterious. She awakened in Spire with a note telling her what she was and that she needed to hide or be killed. She also has been an adult in the city for a long time. For over 30 years, in fact.
A cloaked and masked figure attacks the head of the medusi contingent. Shå arrives too late to stop it, but soon enough to be mistaken for the Soulbreaker by the other medusi.
After a brief skirmish, the mistake is rectified. The medusi tell her they're about to be sent on a mission--a suicide mission--by the Baroness and they ask her to intercede.
Shå has her own problems with the royals. The Baroness publicly chastises her for not catching the murderer yet. She's also in the doghouse with the Baroness' sister-- Shå's girlfriend--because she found out Shå never told her age.
The whole Spire has got bigger problems. The Zaorim are massing for war.