Despite the ubiquity of nonsophont minds, there are still plenty of sophont middle managers, datapushers, administrators, and salarymen, in the ranks of government and corporations. Some of them get tired of jockeying a desk for substandard pay and give it up for something more exciting.
Skills: Bureaucracy, Culture/World, either Culture/Corporate or Profession/Legal, Steward
Small time entrepreneurs and up and coming junior executives exist on every civilized world. Sometimes they chafe against bureaucracy or make some bad decisions and decide to look for better markets.
Skills: Business, Culture/Any, Persuade, Steward
There's a lot of valuable information buried in the depths of a planetary or system noospheres. Data prospectors mine the infospace for value. Sometimes they find things that make them decide to have a look at what's beyond their world for themselves.
Skills: Computer, Culture/Any, Perception, either Bureaucracy or Tech/Any
On every world, in every time, sophonts have wanted to be entertained. Many musicians, thespians, or courtesans, decide to become itinerants, seeing the galaxy as they make their living.
Skills: Art/Any Performing Art, Culture/Artist Subculture, Persuade, one other skill
Everyone uses computers without even thinking about it, but hackers know the very soul of the networks. Some of them are criminals, some of them work to stop criminals. Either way, it can be easy to get on the wrong side of the wrong people and find it expedient to get out of the local jurisdiction.
Skills: Computer, either Bureaucracy, Culture/Corporate or Culture/Criminal, Persuade, Tech/Any but Astronautic, Maltech, or Medical
News is everywhere and journalists are there to sift through the data and bring connection and context to their audience. Some get the idea to go gonzo and get in the stories themselves, while some others make enemies in places of power. Both sorts can be encountered among the Strange Stars.
Skills: Culture/Any, Perception, Persuade, and one other skill.
Beat cop, port authority security contractor, or corporate investigator, the law enforcer does a tough job, often for little reward. Is it any wonder some of them look for a way to put their skills to more lucrative use?
Skills: Combat/Any, Culture/World, Perception, Security
Most actual medicine is before by expert systems and bots, but sophont beings usually like a friendly, sophont face on their healthcare. The medtech provides that. Occasionally, though they have an itch to really put their skills to use in situations where they can't rely on bots to do the real work.
Skills: Profession/Medical, Culture/World, Science, Tech/Medical
In an age of nanopsychotherapy to deal with serious mental illness, the "sophont touch" is still prized--particularly by the wealthy. An understanding of sophont psychology is a skill that has a lot of uses, though.
Skills: Culture/World, Persuade, Profession/Mental Health, either Perception or Tech/Medical