Here's an idea: Take a D&D (mostly 2e) setting and combine it with a non-D&D rpg also published by TSR. Here are a few:
Spelljammer XXVc (Spelljammer + Buck Rogers XXVc)
Buck Rogers is thrown into suspended animation and awakens in a world where magic is ascendant, and Earth is an occupied territory. This winds up being a bit like Shadowrun with rockets (XXVc already had a hint of cyberpunk to it), but the difference is genetic engineering and other high-tech feats would actually be accomplished via magic.
Another Spelljammer combo: Add the Buck Rogers Adventure Game for a pulpier approach.
All Alone in the Night (Ravenloft + Metamorphosis Alpha)
When the generation ship Warden left earth, the monsters went with it, and Dracula takes his real estate schemes to the stars! Like The Starlost, you would need isolated habitats, but here they would be ruled by various horrors. Vampire Hunter D could also be an influence here.
Another Ravenloft option: Mix in Gangbusters with the monsters as mob bosses.