Movie Frankenstein's monster is often a lumbering and destructive brute--and often misunderstood. He reminds me a bit of King Kong in all except size. Scale him up, and you’ve got a kaiju. The Japanese have already done that for us, but hey, we don’t necessarily have to use their version. (Actually, Toho got the idea from an aborted Willis O'Brien project with King Kong.) Now Victor’s got an even better reason not to make him a bride!
Or maybe something less monstrous? A gold-skinned artificial man created by scientists playing God would also describe Marvel’s Adam Warlock (originally known as HIm). Maybe their creation is actually mankind’s natural successor. Gotta make way for the homo superior, as Bowie would have it. This artificial ubermensch and his bride (and progeny) might choose to save the world that hates and fears them, or maybe (in the words of Victor Frankenstein) they’re a “race of devils…propagated upon the earth who might make the very existence of the species of man a condition precarious and full of terror.”
Vampire Hunter D heads straight from Dracula into the post-apocalypse (and in an interesting twist, Mary Shelley did write an end of the world novel, The Last Man), so why not Frankenstein? Maybe the monster is a gunman dispensing justice in a post-apocalyptic waste haunted by mutants as ugly as him, or maybe the world is overrun zombie apocalypse-style by monstrosities created by a monster following in the footsteps of his mad scientist creator? Either the future might be pretty grim.